In the 33rd minute Fati's acceleration then drew a foul in the area from Mario Gaspar and Messi slotted home the penalty to make it 3-0 and Pau Torres scored an own goal with the last action of the first half when he put Messi's clipped ball past the stranded Asenjo under timid pressure from Busquets.
Elsewhere, last season's fourth-placed side Lazio enjoyed a 2-0 away win over Cagliari with goals from Manuel Lazzari and Ciro Immobile.
Chelsea showed both defensive frailty and fighting spirit as they fought back from 3-0 down away to West Brom to claim a 3-3 draw.
Pironkova, 33, who has just returned to the Tour after three years' absence at the US Open and made an impressive run to the quarterfinals, receiving a walkover to the third round in Paris. Enditem
With the result, Hoffenheim capture the top spot with two wins from two games whereas Bayern Munich slip to the 7th position after suffering their first loss in 2020.
The Bianconeri got back on level terms again in the 68th minutes as Ronaldo steered his header into the net on Danilo's cross.
"We are a bit weak in the question of central defenders: with Gerard (Pique) and (Clement) Lenglet and (Ronald) Araujo, we are a bit short ... it is weak for the season that we are going to play," he admitted.
The match had been suspended by a Rio de Janeiro labor court on Saturday but the decision was overturned by a senior judge just 10 minutes before kickoff. The game eventually started more than 20 minutes late.
SHANGHAI, Sept. 30 (Xinhua) -- Chinese E-sports team LGD Gaming beat Australian team Legacy Esports 3-0 to advance into the Group Stage of 2020 League of Legends World Championship (S10) here on Wednesday.
"I am very happy and excited to sign for Maritimo," Alipour was quoted as saying.
Some fans and pundits fear Flick could soon be fed up with his side's strategy to avoid costly transfers and follow what many call a healthy spending policy.